Brain Receptors for Marijuana/Cannabis

October 20th, 2008  |  Published by BRAHA Editor in Psychoactive Substances

By William M. Bennett

The pro-legalization activists have been making much ado about the fact that the brain has receptors that bind to cannabinoids, and thus are called cannabinoid receptors.

The body produces many chemicals and hormones, i.e., histamines, steroids, thyroid hormone, digitalis-like substances, adrenalin, etc, all of which work by attaching to corresponding brain receptors. The key is that these natural substances produced by the body are present in nanogram amounts (1billionth of a gram) versus the size of a dose that would be given medicinally, which are hundreds of thousands of times larger. The body does not naturally produce THC, the psychoactive ingredient in cannabis, but instead produces a non-psychotropic substance referred to as a cannabinoid because it binds to the same receptor that THC does. The action of substances which activate the receptor and are known as agonists, remains unknown. Other substances besides agonists can also bind to the receptor and block or inactivate its action. These substances are call antagonists. The fact that the brain has receptors to which THC can bind and cause its multiple psychotropic problems in no way indicates that man was “meant” to indulge in smoking pot

Author: William M. Bennett
Source: Northwest Center for Health & Safety

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